Preventing Sudden Cardiac Death Following Percutaneous Revascularization
- Volume 20 - Issue 6 - June 2012
- Posted on: 6/4/12
- 0 Comments
A 68-year-old male with a known history of tobacco abuse, coronary artery disease, and previous myocardial infarction presented to the emergency room after experiencing chest pressure. He had multiple stents placed 10 years prior and additional stents placed three months prior to this admission. He had been experiencing symptoms for approximately three hours.
The patient was in moderate distress. Electrocardiogram revealed ST elevations in leads II, III, and aVF with ST depressions in leads V2 through V5 consistent with acute injury of the inferior and posterior walls of the left ventricle (Figure 1). The patient received aspirin, heparin, and a beta blocker. Given the patient’s additional history of contrast dye allergy, he also received intravenous hydrocortisone, Benadryl, and an H2 antagonist, and was taken to the cardiac catheterization laboratory emergently for angiography and percutaneous revascularization.
Cardiac catheterization revealed:
Left main: Normal.
Left anterior descending artery: Patent stents in the proximal and mid segments.
Left circumflex artery: 100% occlusion in the mid vessel within previously deployed stents, consistent with stent thrombosis (Figure 2A); dominant vessel.
Left ventricle: Posterobasal hypokinesis; ejection fraction (EF) of 30% to 35%.
The decision was made to intervene on the acutely occluded left circumflex artery. A guide wire was advanced into the left circumflex artery through the occlusion in the stents using the support of an over-the-wire balloon (Figure 2B). The balloon was advanced and several inflations were made within the stent. The balloon was then removed, and angiography revealed restoration of TIMI-2 to TIMI-3 flow throughout the stent, with visualization of significant residual stenosis and thrombus. A thrombus aspiration catheter was advanced into the occluded stent and two passes were made. The catheter was removed and a balloon was advanced into the stent and inflated several times. The balloon was removed and angiography revealed an excellent result, with TIMI-3 flow throughout the left circumflex artery (Figure 2C). The patient had resolution of ST elevation (Figure 3) and complete resolution of his chest discomfort.
The patient received a loading dose of prasugrel 60 mg orally (in place of clopidogrel, which he had been on until this hospital admission), and was transferred to the ICU. A two-dimensional echo revealed an ejection fraction of 30-35%. Due to his low ejection fraction, he was ordered a wearable cardioverter defibrillator (WCD), (LifeVest®, Zoll) before discharge. The patient’s remaining hospital stay was unremarkable and he was discharged two days later.
Upon returning home with friends, the patient let his pets out in the yard and went back into his house to feed them. At this point, the patient experienced an episode of ventricular tachycardia (VT) at a rate of 242 beats per minute; his WCD appropriately detected the episode and started broadcasting alarms. The patient fell unconscious and the WCD delivered a 150J biphasic treatment shock 58 seconds after detection (Figure 4). The patient’s friends drove him to the hospital.
The patient was hospitalized and received an implantable cardioverter defibrillator (ICD). The patient was discharged and continues to do well.
This patient had known coronary artery disease and had a stent procedure of his left circumflex artery approximately three months earlier. He was doing very well after that procedure. In fact, he was preparing to ride his motorcycle in an organized charity ride when he started to experience chest discomfort. He called his daughter who transported him to the emergency room where he was transferred emergently to the cardiac catheterization lab. The patient underwent an intervention resulting in successful recanalization of his stent. After the procedure, the patient was treated as a clopidogrel non-responder and started on prasugrel.
This patient’s post-PCI EF was 30-35% and the decision was made to first optimize medical therapy with the goal of improving left ventricular function. It is known that the risk of sudden cardiac death (SCD) is increased in patients with an ejection fraction less than 35-40%.1 To provide protection from SCD while medical therapy was titrated, a WCD was prescribed. On the day of his discharge, the patient experienced a life-threatening arrhythmia that was appropriately treated by the WCD.
Post-MI patients with low ejection fractions are known to have significant risk of SCD in the early period following PCI.2-4 The EF threshold for increased SCD risk is known to be to 35-40%. Managing this risk requires consideration of many factors, including consideration of ICD waiting criteria (40 days post-MI and 90 days post-revascularization), optimizing medical therapies, and ensuring patients who would benefit from an ICD return for evaluation and implantation. The dramatic, day-of-discharge, life-saving therapy delivered by the WCD in this case demonstrates the risk of SCD that post-PCI patients with low EFs face in the first three months following their cardiac event. This case also demonstrates the importance of proper SCD risk screening and, where risk is determined to be present, acting to ensure the patient is appropriately protected from SCD until their long-term arrhythmic risk can be determined.
Dr. Goodfellow can be contacted at firstname.lastname@example.org.
Disclosure: Dr. Goodfellow reports no conflicts of interest regarding the content herein.
- Buxton AE, Lee KL, Fisher JD, Josephson ME, Prystowsky EN, Hafley G. A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. N Engl J Med 1999;341:1882-1890.
- Toda K, Mackenzie K, Mehra MR, DiCorte CJ, et al. Revascularization in severe ventricular dysfunction (15% < OR = LVEF < OR = 30%): a comparison of bypass grafting and percutaneous intervention. Ann Thorac Surg 2002 Dec; 74(6): 2082-2087; discussion 2087.
- Halkin A, Singh M, Nikolsky E, Grines CL, et al. Prediction of mortality after primary percutaneous coronary intervention for acute myocardial infarction: the CADILLAC risk score. J Am Coll Cardiol 2005 May 3;45(9):1397-405.
- Stone GW, Rao SV, Hermiller JB, Kadish A. Prevention of sudden cardiac arrest post PTCA in high-risk patients. Medscape Education Cardiology. Available online at http://www.medscape.org/viewarticle/741503. Accessed May 15, 2012.
BEHIND THE CASE
Real-World Use of the ZOLL LifeVest: A Wearable Cardioverter Defibrillator
Cath Lab Digest talks with Ross J. Goodfellow, DO, FACC, FSCAI, Health First Cardiovascular Specialists, Merritt Island, Florida.
Tell us about your practice.
I am an interventional cardiologist in a multi-specialty group with five cardiologists and over a hundred physicians. We are owned by Health First, which operates four not-for-profit hospitals. The hospital where the case took place was at Cape Canaveral Hospital in Cocoa Beach, Florida, which has two cath labs.
How did you determine the patient featured in your case study was at high risk for sudden cardiac death?
This gentleman was someone who had known coronary artery disease and was found to have a fair amount of left ventricular dysfunction following the procedure. Typically, if someone comes in with an acute myocardial infarction (MI), they wind up getting some assessment of their left ventricular function, if not during the catheterization itself, then certainly by echocardiogram. This is one way to assess risk for sudden cardiac death, and certainly the gentleman in question was having a fair amount of ventricular ectopy while he was hospitalized after the event, which made him particularly high risk.
What are some of the challenges in managing patients at high risk for sudden cardiac death?
Management is always a challenge in someone who has had recurrent coronary intervention. There are always compliance issues — emphasizing to the patient that they need to be very diligent about taking their medications as prescribed. Other challenges would include trying to keep them out of the hospital for not only anginal chest pain, but also congestive heart failure and other kinds of cardiac issues. Arrhythmias are, of course, a concern. Many of these people have co-morbidities such as diabetes and kidney disease, which make it challenging because we have to coordinate with other specialists on the patient’s medical regimen.
Describe your experience with the LifeVest.
I first became familiar with the LifeVest through one of my colleagues who is in electrophysiology, and through in-servicing by the company representatives. At first I wasn’t quite sure whether it would actually work, but the LifeVest has delivered life-saving therapy to my patients, both to ischemic cardiomyopathy patients like the one I describe in the case study, and to non-ischemic cardiomyopathy patients. It is effective. The nice thing is that the LifeVest can record arrhythmias and function like a Holter monitor, so we can learn whether the patient is having other, less-than-life-threatening arrhythmias, such as atrial fibrillation. There are not many things out there in medicine that clearly make a difference in terms of life-saving therapy. Defibrillators in general, including the LifeVest, certainly do make a difference in saving lives.
How has it changed your patient management?