June 25, 2020 — A persistent cough and fever have been confirmed as the most prevalent symptoms associated with COVID-19, according to a major review of the scientific literature.
Other major symptoms include fatigue, losing the ability to smell and difficulty in breathing.
The study ratifies the list of symptoms listed by the World Health Organisation at the start of the pandemic.
The researchers -- from five universities including the University of Leeds in the UK -- combined data from 148 separate studies to identify the common symptoms experienced by more than 24,000 patients from nine countries, including the UK, China and the US.
The study -- published in the online journal PLoS ONE -- is one of the biggest reviews ever conducted into COVID-19 symptoms. The researchers also acknowledge there is likely to be a large proportion of people who had the virus but did not display symptoms .
Of the 24,410 cases, the study found:
- 78 percent had a fever. Although this tended to vary across countries: with 72 percent of fever reported by patients in Singapore and 32 percent in Korea.
- 57 percent reported a cough. Again, this varied across countries, with 76 percent of patients reporting a cough in the Netherlands compared to 18 percent in Korea.
- 31 percent said they had suffered fatigue.
- 25 percent lost the ability to smell.
- 23 percent reported difficulty breathing.
The researchers believe the variation in the prevalence of symptoms between countries is due, in part, to the way data was collected.
Of those patients who needed hospital treatment, 17 percent needed non-invasive help with their breathing; 19 percent had to be looked after in an intensive care unit, nine percent required invasive ventilation and two percent needed extra-corporeal membrane oxygenation, an artificial lung.
Ryckie Wade, a surgeon and Clinical Research Fellow at the Leeds Institute of Medical Research, supervised the research. He said: "This analysis confirms that a cough and fever were the most common symptoms in people who tested positive with COVID-19."
"This is important because it ensures that people who are symptomatic can be quarantined, so they are not infecting others.
"The study gives confidence to the fact that we have been right in identifying the main symptoms and it can help determine who should get tested."
The study involved academics from the University of Leeds with colleagues from the University of Sheffield, University of Bristol, Imperial College, London, and the Belgium Cancer Centre. The research was funded by the UK's National Institute for Health Research and VALCOR, in Belgium.
- Michael C. Grant, Luke Geoghegan, Marc Arbyn, Zakaria Mohammed, Luke McGuinness, Emily L. Clarke, Ryckie G. Wade. The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries. PLOS ONE, 2020; 15 (6): e0234765 DOI: 10.1371/journal.pone.0234765