New research shows patients with a history of chest discomfort due to coronary artery disease who are subsequently diagnosed with depression are much more likely to suffer a heart attack or die compared with those who are not depressed. The study was presented at the American College of Cardiology’s 65th Annual Scientific Session.
These results are in line with previous research showing that depression is associated with worse outcomes after a heart attack or bypass surgery. But this is the first large population study to look at how a new diagnosis of depression might affect people with coronary heart disease, according to researchers.
The study included 22,917 patients from 19 medical centers in Ontario, Canada, who received a diagnosis of stable coronary artery disease (CAD) following coronary angiogram for chronic stable angina between Oct. 1, 2008, and Sept. 30, 2013. Individuals with CAD who were found to be depressed were 83 percent more likely to die of any cause compared with those with the same condition who were not depressed during follow-up (average of three years). They were also 36 percent more likely to present at a hospital having a heart attack during the same time period. Depression did not, however, impact the likelihood of needing bypass surgery or coronary stent placements.
Any screening should be done at regular intervals of time to avoid missed opportunities to intervene, researchers note. Patients diagnosed with depression were more likely to be women and report more severe chest pain based on a validated angina scale. Other factors that predicted depression included smoking, diabetes or having a greater number of co-existing medical conditions.
To be included in this study, patients had to show evidence of more than 70 percent narrowing in coronary arteries and more than 50 percent in the left main coronary artery. Researchers excluded patients if they had a history of depression or ever had a heart attack, other cardiac event requiring hospitalization, bypass surgery, or a stent placed. Physician billing codes and hospital admissions were used to determine new diagnoses of major depression. Data was collected for all-cause mortality and time to readmission for heart attack and revascularization, and analyses controlled for other cardiovascular risk factors.
Researchers caution that the study design may have captured patients with psychosocial distress in addition to major depressive disorder, which could have diluted the findings, meaning that the impact of depression on outcomes could be even stronger in patients with true depression. The research is also restricted to patients who had a coronary angiogram, who may have had more severe disease or symptoms.
Additional studies are needed to evaluate the utility of screening for and treating depression in this population. The study was funded by the Canadian Institute of Health Research and the Sunnybrook Health Sciences Centre.